Causes And Effect of Antisperm Antibodies On Fertility

Causes And Effect of Antisperm Antibodies On Fertility


Sperm is the most essential factor for a successful pregnancy which contains the genetic material of the men and swims towards the egg for fertilization. However, in some cases when men or women are suffering from anti-sperm antibodies, this sperm is attacked by the immune system as it is considered an invader. 

This health condition makes it extremely difficult to get pregnant and can be considered as an immunologic infertility. If you’re facing issues conceiving even after trying unprotected intercourse for 12 months, then you must visit the best centre for IVF in North Bengal

Causes Of Antisperm Antibodies In Male

Men with a history of prostate infections such as chronic prostatitis increase the chances of prostatitis triggers. These triggers can lead to an imbalance in anti and pro-oxidative factors within semen and this contributes to the production of the antisperm protein. In some cases, previous surgery or injuries can also cause anti-sperm antibodies. 

This is because, injuries can breach the barrier between blood and testis and this may expose the sperm to the immune system. This triggers an inflammatory response leading to the generation of antibodies. Additionally, the risks of developing these antibodies also increase among vasectomized patients and patients with hernia due to the obstruction caused in the vas deferens. 

Causes Of Antisperm Antibodies In Female

Certain allergic reactions in the body towards sperm can enhance the risks of producing antisperm antibodies in the female reproductive system. In this kind of reaction, the antibodies created in the vagina kill the sperm. This condition is often rare but can become a major barrier to fertility. 

The chemical disruption created in the mucosal layer of the genital tract leads to the production of a type of cervicovaginal secretions that contain antisperm antibodies. Certain infections such as pelvic inflammatory disease and sexually transmitted infections can also higher the chances of production of these antibodies in females. 


Antisperm antibodies are one of the leading causes of infertility cases. If the male partner is suffering from this issue, then it may negatively impact sperm motility, and quality and can also lead to low sperm count. This decreases the chances of the sperm reaching the egg by passing through the cervical mucus. 

Additionally, if the female partner is suffering from antisperm antibodies then it will severely hinder the fertilization process by killing the sperm even before it reaches the egg. These antibodies can also increase the histamine secretion which may destroy an implanted embryo.

Treatment Options 

After an anti-sperm antibody test, the doctor may recommend medications to control the immune response in men. This will help increase the chances of successful pregnancy. Sperm washing is another method that can used to reduce the number of affected sperm. 

The remaining healthy sperm will be then collected and inserted through the vagina by the intrauterine insemination (IUI) method. The doctor may also recommend IVF treatment to women suffering from this condition. 

You can book an appointment with a reputed centre for IVF in North Bengal if you are experiencing any symptoms of infertility or have tested positive for an anti-sperm antibodies test. There are effective assisted reproductive technology methods that can help you in getting pregnant.

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